Author: Keshva Pai, Kiran Haridas, K.N.S.Roa, Indrani Poddar, Vikram Haridas.
Year: 2008
Source: ASEAN Journal of Psychiatry. Vol. 9, Supplement 1, 26-29 August 2008, page 43-44.
Objective: To compare the efficacy, tolerability and safety between Memantine and Donepezil in moderate to severe Alzheimer’s disease. Methods: It is an open labeled randomized comparative study between Memantine (NMDA receptor atagonist) 20mg/day and Donepezil (cholinesterase inhibitor) 5-10mg/day in Alzheimer’s disease in 22 patients in two equal groups over duration of 28 weeks. The primary efficacy measure was the mean total change in Functional Dementia Scale (FDS) and Care Giver Burden sc...