ผู้วิจัย/Authors: suthan chantawong, pattharee paholpak, suchat paholpak, samai junnamom

ชื่อเรื่อง/Title: A Retrospective Study of the Adverse Effects of Second Generation Antipsychotics at the Psychiatric Outpatient Clinic in Srinagarind Hospital.

แหล่งที่มา/Source: Journal of the Psychiatric Association of Thailand, Vol 62, No 1, January-Marchr 2017, Page 74-82.

รายละเอียด / Details:

Objective: To study the rate of sdverse drug reaction that occureed in psychiatric patients treated with second generation antipsychoticsat the psychiatry outpatient clinic, Srinagarind Hospital.

Method: This was a descriptive retrospective study. The purpose was to review the occurrence of adverse drug reactions from second generation antipsychotics recorded in the medical records of all psychiatric outpatients of Srinagarind hospital during January 2004 to December 2014 (11 years). Then occurrences of adverse drug reactions were recorded by Thai Medical Council certified psychiatrists and psychiatric residents who were under supervision by any certified psychiatrists.

Results: Two-hundred and forty-two medical records were reviewed, 118 of which were male (48.8%) and 124 were female (51.2%). Their mean age+-SD was 47.5+-19.6, median age was 48.0 years old. There were patients with schizophrenia for 48.4% and bipolar disorder for 15.9%. The most frequent adverse drug reaction was weight gain (33.8%) which was caused by olanzapine (54.6%) and clozapine (43.3%). The second most frequent adverse drug reaction was extrapyramidal side effect (EPS; 10.8%), most of which were caused by paliperidone and ziprasidone (35.7%) and 28.6%) respectively). The third most frequent adverse drug reaction was sedation (4.8%) which was caused by all second-generation antipsychotics in an equal rate except not any record was for quetiapine. Metabolic syndrome was found only 2.2%, the cause of which was aripiprazole.

Conclusion: The most frequent adverse drug reaction from second generation antipsychotics in descending order were weight gain, EPS and sedation. Weight gain was mostly from olanzapine, EPS from paliperidone; and sedation from any second-generation antipsychotics. Metabolic syndrome was found in very few rates.

Keywords: adverse drug reaction, second generation antipsychotics, weight gain, extrapyramidal side effect, sedation

ปีที่เผยแพร่/Year: 2017

Address: Division of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Khon Kaen University

Code: 2017000050

ISSN/ISBN: 0125-6985

Country of publication: Thailand

Language: English

Category: Abstract

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