ผู้วิจัย/Authors: tanya vichaikoslo, pichai ittasakul, varinee lekprasert

ชื่อเรื่อง/Title: Effect of Ketamine Plus Electroconvulsive Therapy (ECT) in Treatment of Major Depresive Episode: A Pilot Study.

แหล่งที่มา/Source: Journal of the Psychiatric Association of Thailand, Vol 62, No 1, January-Marchr 2017, Page 83-94

รายละเอียด / Details:

Objective: To assess the efficacy of ketamine plus electroconvulsve therapy (ect) compare with ect alone for treatment of major depressive episode in major depressive disorder and bipolar disorder.

Method: A double-blind randomized control trial was conducted between July 2015 to July 2016. Subjects included patients with major depressive episode who received inpatient ECT at department of psychiatry, Ramathibodi Hospital, Bangkok. Twelve patients were randomized into 2 groups, the experimental group received ketamine 0.5mg/kg plus ECT (n=7) and control group received ECT alone (n=5). Montgomery-Asberg depression scale (MADRS) was used to assess depresive symptoms at baseline, after first ECT, after third, then after three consecutive ECTs until the end of treatment. Hemodynamic changes and adverse events were recorded.

Results: MADRS score of experimental group had greater decrease than control group after third ECT evaluation (p=0.047). Ramission rate after sixth ECT evaluation in experimental group was higher than control group (p=0.048). No statistical significance between control and experimental group was detected in hemodynamic changes and adverse events.

Conclusion: Intravenous injection of ketamine 0.5mg/kg plus ECT could accelerate the effect of ECT in depressive patients during the initial phase. But ketamine injection does not increase the effect of ECT at the end of treatment.

Keywords: ketamine, electroconvulsive therapy (ect), major depressive episode

ปีที่เผยแพร่/Year: 2017

Address: Department of psychiatry, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Code: 2017000049

ISSN/ISBN: 0125-6985

Country of publication: Thailand

Language: English

Category: Abstract

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