ผู้วิจัย/Authors: Chutamanee Suthisisang Ph.D. (Pharm)

ชื่อเรื่อง/Title: Serotonin-dopamine antagonists concepts in psychiatry

แหล่งที่มา/Source: Journal of The Psychiatric Association of Thailand, Vol. 41 No.1 January-March 1996, 55-64

รายละเอียด / Details:

Abstract Serotonin-dopamine antagonists (SDAs) are novel antipsychotics which have different pharmacological properties from conventional antipsychotics. SDAs possess potent 5-HT2A receptor and weak D2 receptor antagonism, whereas conventional antipsychotics such as haloperidol blocks D2 receptors with higher affinity than 5-HT2A receptors. From their distinct receptor profiles, SDAs effectively reduced negative symptoms and produced less extrapyramidal side effect than conventional antipsychotics, however they are equally potent to conventional agents in treating positive symptoms. A number of SDAs drugs are being developed which will provide new modalities in treating schizophrenic patients and their clinical efficacy remains an issue to be verified.

Keywords: serotonin-dopamine antagonists, pharmacology, risperidone, antipsychotic drugs, drug, biology

ปีที่เผยแพร่/Year: 1996

Address: Department of Pharmacology, Faculty of Pharmacology, Mahidol University, Sri Ayudhaya Road, Bangkok 10400

Code: 0000045

ISSN/ISBN: 0125-6985

Country of publication: Thailand.

Language: English.

Category: Abstract Journal.

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