ผู้วิจัย/Authors: Worrawat Chanpattana, Somchai Charkrabhandu

ชื่อเรื่อง/Title: Seizure Threshold Changes During Acute and Maintenance ECT in Schizophrenic Patients.

แหล่งที่มา/Source: Journal of The Psychiatric Association of Thailand, Vol. 45 No.2 April-June 2000 P 129-144.

รายละเอียด / Details:

Objective This prospective study aims to determine changes in seizure threshold during acute and maintenance electroconvulsive therapy (ECT). Method Seizure threshold was estimated by the empirical titration technique in 41 patients with schizophrenia from the beginning of acute ECT (Phase I) to the end of one-year maintenance ECT (Phase II). In Phase I, initial threshold was estimated at the first two treatment sessions, then the thresholds were quantified at the seventh, fourteenth, and twentieth ECT. During Phase II, seizure thresholds were estimated at the first treatment, then every 3 months for 1 year. Results All patients had a rise in seizure threshold at the end of Phase I, which the magnitude of increase was 213 + 179%. Number of ECT treatments and onset of illness could predict the threshold-increase of Phase I. At the end of Phase II, fifteen patients had no change in thresholds compared to the first estimates of Phase II; eighteen others showed a further increase, and thresholds of the last eight patients decreased gradually. The magnitude of threshold-increase of Phase II was 17 + 43%. An overall increase of thresholds at the end of Phase II was 243 + 178%. Conclusions Increases in seizure threshold seen during acute ECT are robust, but generally sustained during maintenance ECT in remitted patients with schizophrenia. Seizure threshold should be estimated regularly during the courses of acute and maintenance ECT.

Keywords: seizure threshold, acute and maintenance ECT, empirical titration technique, anticonvulsant effect, schizophrenia, psychiatry, psychosis

ปีที่เผยแพร่/Year: 2000

Address: Department of Psychiatry, Srinakharinwirot University, 681 Samsen, Dusit, Bangkok 10300.

Code: 00000309

ISSN/ISBN: 0125-6985

Country of publication: Thailand.

Language: English.

Category: Abstract Journal.

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